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SAM-e plays an important role in cartilage formation and repair. In in vitro studies, SAM-e has been shown to increase the blood levels of proteoglycans, which are the starting point of cartilage formation. SAM-e has been shown in a number of studies to bring arthritis pain relief comparable to that of the often prescribed NSAIDs, naproxin and piroxicam - without their side effects. In a study performed in 1990 at the Instituto de Docencia e Investigaciones Biologicas, in Buenos Aires, Argentina, arthritis was induced in the right knee of 24 rabbits. The rabbits were divided into 3 groups and treated intramuscularly with 30, 60 or 0 (diluent only) mg of SAM-e. After 12 weeks the knees were examined and it was found that the greater the amount of SAM-e given to the rabbit, the greater the concentration of proteoglycans was found in the cartilage (proteoglycans serve as attachment points for glucosaminoglycans). And, most importantly, people report significant relief from supplementation with SAM-e.*



* The information contained herein was gathered from various scientific studies conducted by professionals both domestically and abroad. These statements have not been evaluated by the FDA. Therefore, this product, being sold as a food supplement, is not intended to diagnose, treat, cure, or prevent any disease.
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