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Clinical Studies

Area of Study	Year	Study	Author	Journal	Length
Mood	1994	S-adenosylmethionine blood levels in major depression: changes with drug treatment	Bell K	Acta Neurol Scand	4 wks
Mood	1994	S-adenosyl-l-methionine (SAM-e) as antidepressant: meta-analysis of clinical studies	Bressa GM	Acta Neurol Scand Suppl	Meta-analysis
Mood	1992	Oral s-adenosylmethionine in depression	De Vanna M	Curr Ther Res	6 wks
Mood	1990	Oral s-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial	Kagan B	Am J Psychiatry	21 d
Mood	1990	The antidepressant potential of oral S-adenosyl-l-methionine	Rosenbaum J	Acta Psychiatr Scand	6 wks
Liver Function	1999	S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial	Mato J	J Hepatol	2 yrs
Liver Function	1989	Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease	Vendemiale G	Scand J Gastroenterol	6 mo
Liver Function	1990	Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study	Frezza M	Gastroenterol	2 wks
Liver Function	1990	Biochemistry and pharmacology of S-adenosyl-L-methionine and rationale for its use in liver disease	Chawla RK	Drugs	Review
Joint Health	1987	Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease	Caruso I	Am J Med	30 d
Joint Health	1987	Double-blind controlled clinical trial of oral S-adenosylmethionine versus piroxicam in knee osteoarthritis	Maccagno A	Am J Med	84 d
Joint Health	1987	A new medical approach to the treatment of osteoarthritis. Report of an open phase IV study with ademetionine (Gumbaral)	Berger R	Am J Med	8 wks
Joint Health	1987	A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis	Konig B	Am J Med	24 mo
Joint Health	1987	Double-blind clinical trial of S-adenosylmethionine versus ibuprofen in the treatment of osteoarthritis	Muller-Fassbender H	Am J Med	4 wks

* The information contained herein was gathered from various scientific studies conducted by professionals both domestically and abroad. These statements have not been evaluated by the FDA. Therefore, this product, being sold as a food supplement, is not intended to diagnose, treat, cure, or prevent any disease.

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