| S-adenosylmethionine blood levels in major depression: changes with drug treatment |
| Authors |
Bell KM, Potkin SG, Carreon D, Plon L |
| Journal |
Acta Neurol Scand Suppl 1994;154:15-18 |
| Comparator |
Oral desipramine |
| # subjects |
26 |
| # on SAM-e |
11 |
| Dose |
1600 mg/day |
| Duration |
4 weeks |
| End results |
- Response rate comparable for both treatment arms
- Significant correlation between plasma SAM-e levels and degree of clinical improvement suggests SAM-e plays an important role in regulating mood
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