| Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease |
| Authors |
Caruso I, Pietrogrande V |
| Journal |
Am J Med 1987;83 (5A):66-71 |
| Comparator |
Placebo, Naproxen 750 mg/day |
| # subjects |
734 |
| # on SAM-e |
248 |
| Dose |
1200 mg/day |
| Duration |
30 days |
| End results |
- SAMe was equally as effective as naproxen; both were significantly more effective than placebo (P < 0.01)
- SAMe was significantly better tolerated than naproxen (P < 0.025 for physicians' evaluation; P < 0.01 for patients' evaluation)
- No difference in side effects between SAMe and placebo
|
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