| Oral S-adenosylmethionine in depression |
| Authors |
De Vanna M, Rigamonti R |
| Journal |
Curr Ther Res 1992;52:478-485 |
| Comparator |
Imipramine 140 mg/day |
| # subjects |
30 |
| # on SAM-e |
15 |
| Dose |
1600 mg/day |
| Duration |
6 weeks |
| End results |
- Patients treated with SAM-e showed significant improvement from baseline in depressive scores (P < 0.01)
- Response with SAM-e was comparable to imipramine
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