| Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial |
| Authors |
Kagan BL, Sultzer DL, Rosenlicht N, Gerner RH |
| Journal |
Am J Psychiatry 1990;147:591-595 |
| Comparator |
Placebo |
| # subjects |
15 |
| # on SAM-e |
9 |
| Dose |
1600 mg/day |
| Duration |
21 days |
| End results |
- Placebo-treated patients showed no significantly lower Hamilton score until day 14; SAM-e treated patients had significantly lower scored by day 7 (P < 0.01)
- Results suggest SAM-e is safe and effective, with few side effects and a rapid onset of action
- Treatment with SAM-e may be useful for patients who cannot tolerate tricyclic antidepressants
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