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The antidepressant potential of oral S-adenosyl-l-methionine
Authors Rosenbaum JF, Fava M, Falk WE, Pollack MH, Cohen LS, Cohen BM, Zubenko GS
Journal Acta Psychiatr Scand 1990;81:432-436
Comparator Open-label, including patients nonresponsive to other antidepressants
# subjects 20
Dose 1600 mg/day
Duration 6 weeks
End results
  • Full antidepressant response seen in 7 of 11 non-treatment-resistant patients and 2 of 9 treatment-resistant patients
  • Side effects were mild and transient
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