| Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease |
| Authors |
Vendemiale G, Altomare E, Trizio T, Le Grazie C, Di Padova C, Salerno MT, Carrieri V, Albano O |
| Journal |
Scand J Gastroenterol 1989;24:407-415 |
| Comparator |
Active-treated patients with alcoholic liver disease and with non-alcoholic liver disease, placebo-treated patients with alcoholic liver disease, and normal control group |
| # subjects |
39 |
| # on SAM-e |
16 |
| Dose |
1200 mg/day |
| Duration |
6 months |
| End results |
- Patients treated with SAM-e showed a significant increase in hepatic glutathione levels as compared with placebo-treated patients
- Suggests SAM-e plays a role in reversing hepatic glutathione in patients with liver disease
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