| Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study |
| Authors |
Frezza M, Surrenti C, Manzillo G, Fiaccadori F, Bortolini M, Di Padova C |
| Journal |
Gastroenterol 1990;99:211-215 |
| Comparator |
Placebo |
| # subjects |
220 |
| # on SAM-e |
110 |
| Dose |
1600 mg/day |
| Duration |
2 weeks |
| End results |
- Serum markers of cholestasis significantly decreased in patients receiving SAM-e (P < 0.01)
- Serum levels were significantly lower in SAM-e-treated patients than placebo-treated patients (P < 0.01)
- SAM-e patients reported a significant improvement in subjective symptoms such as pruritus, fatigue, and feeling unwell (P < 0.01)
- SAM-e was tolerated as well as placebo
|
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