| Biochemistry and pharmacology of S-adenosyl-L-methionine and rationale for its use in liver disease |
| Authors |
Chawla RK, Bonkovsky HL, Galambos JT |
| Journal |
Drugs 1990;40 (Suppl 3):98-110 |
| Type of article |
Review |
| End results |
- Cirrhotic patients have acquired metabolic block in hepatic conversion of methionine to SAM-e
- Limited availability of hepatic SAM-e may lead to cysteine and choline deficiencies
- SAM-e supplementation facilitates endogenous cysteine and choline production and correct negative nitrogen balance
- SAM-e may be considered an essential nutrient required to normalize overall hepatic transmethylation and transsulfuration activities
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