SAMe & joint

SAMe and the Human Body
SAMe (pronounced “Sammy”), or S-Adenosyl-Methionine, is a natural substance synthesized from methionine (an amino acid) in the body. SAMe is a compound that is found naturally in every living being. One of the most important functions of SAMe is its role as a methyl donor. As a methyl donor, SAMe carries and donates methyl molecules to various parts of the body. This process is what enables many cells in the body to work. It is therefore critical to have adequate levels of SAMe in order for the body to work properly.

How does SAMe affect joints?
Naturally occurring SAMe plays a critical role in joint health. During the process of aminopropylation – the process by which SAMe is converted into antioxidants – methylthioadenosine (MTA) is produced. MTA helps support cartilage matrix production in the joints, and may help maintain the effectiveness of proteoglycans, molecules that are critical for the lubrication of joints. Proteoglycans are a part of cartilage which allows for movement of the cartilage and shock absorption.

Studies indicate that SAMe may increase the production of chondrocytes as well. Chondrocytes are cartilage cells. Cartilage is a sponge-like substance that is found between bones in joints, that cushions the bone and protects them from rubbing against each other. If cartilage is depleted, it can cause painful scraping of bone on bone.
If the body is not producing enough SAMe, cartilage and proteoglycan production may be disrupted and may be a cause of joint discomfort.

What SAMe supplementation can do for you?
Normally, the body produces enough SAMe on its own from the amino acid methionine. However, as people age (beginning as early as the teenage years), SAMe levels can decrease. Taking SAMe as a supplement may help replenish low levels, and may help the body resume its normal function. Healthy levels of SAMe can help maintain joint flexibility and comfort.