The goal of taking SAMe as a supplement is to boost the amount of SAMe in the body to healthy levels so that the body can operate normally. Boosting SAMe levels to normal will not disrupt parts of the body that are not affected by low levels of SAMe.
One of the advantages of SAMe is its remarkable safety profile. SAMe has been safely administered for over 30 years. In very rare cases, SAMe may cause some slight stomach discomfort, which is not dangerous. This can usually be rectified by taking SAMe together with a light snack. There are no known adverse reactions between SAMe and other prescription medications. However, if you are taking any medication or are under a doctors care for a medical condition, please consult your doctor before using this product. If you are pregnant or nursing, please consult with your doctor before taking this product. If you are suffering from bipolar disorder or manic depression, do not take SAMe.
SAMe is best absorbed by the body when taken on an empty stomach. Therefore, the optimal time to take it is first thing in the morning, about a half-hour before breakfast. Otherwise, it can be taken thirty minutes after a meal.
Yes, you can divide your dose over the course of the day.
No. Since SAMe is best absorbed by the body in the small intestines, it is enteric coated which protects it from breaking down in the stomach, and allows it to enter the small intestines intact. Breaking or crushing the tablet exposes the SAMe, and will not be absorbed as effectively.
The two most important things to look out for when buying a SAMe is supplement is as follows:
1- Enteric coating: SAMe is best absorbed by the body in the small intestines. Enteric coating protects the tablet from breaking down in the stomach and allows it to enter the small intestines intact.
2- Blister packed: SAMe is a very sensitive product and can degrade when exposed to heat or moisture. Blister packed tablets ensure that the tablet is protected until right before use.
As with all dietary supplements, consult your physician before starting a new dietary supplement. If you are pregnant or lactating, consult your physician before taking SAMe. If you suffer from bipolar disorder or manic depression, do not use this product. If you are under a doctor’s supervision for a medical condition, consult before starting SAMe. If you are currently taking any prescription medication, consult with your doctor before taking SAMe.
While there are no studies indicating that taking SAMe during pregnancy is dangerous, there has not been enough clinical studies conducted to determine that it is safe during pregnancy. Pregnant women should consult their doctor before taking SAMe.
Most people find 400mg – 800mg of SAMe a day to be sufficient. You may need to increase or decrease your daily intake according to your symptoms. It is safe to take up to 1600mg per day.